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  • Cyclosporine was the most commonly used agent 5 years ago, but, currently, almost half of pediatric heart transplant recipients are receiving tacrolimus.
  • Thus pinocytosis offers a pathway through which large macromolecules, which are otherwise incapable of passing through the membrane, may be taken up by cells.
  • Corticosteroids prevent immune activation by inhibiting antigen presentation, cytokine production, and proliferation of lymphocytes.
  • Indeed, some peptides and proteins are known to enter intestinal mucosal cells through pinocytosis; furthermore, a few peptides and proteins including immunoglobulin G, nerve growth factor and epidermal growth factor have been reported to reach blood vessels in the lamina propria and the portal venous circulation.

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